Llord Zenjen Carame on LinkedIn: 3 Best Methylfolate™ Calcium L 5 Methyltetrahydrofolate Uses (2024)

FAQs

What is l-methylfolate 5-MTHF used for? ›

Therapeutically, 5-MTHF is instrumental in reducing hom*ocysteine levels, preventing neural tube defects, and improving vascular endothelial function.

Levomefolic acid (INN, also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of hom*ocysteine.

L 5 METHYLTETRAHYDROFOLATE CALCIUM is used to treat folate deficiency (low levels of folate) and anaemia (lack of red blood cells). It is useful in treating low folate levels caused by poor diet, pregnancy, alcoholism, and other disease conditions.

L-methylfolate is a medical food for use in people who have conditions related to folate deficiency. L-methylfolate is also used in people with major depressive disorder who have folate deficiency, or in people with schizophrenia who have hyperhom*ocysteinemia related to folate deficiency.

This medication contains L-methylfolate. Do not take Deplin if you are allergic to L-methylfolate or any ingredients contained in this drug. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

As with almost any supplement, this is not something you should take forever. Nor even everyday in most cases, but rather as a complementary medicine prescribed by your doctor. L-methylfolate also exists naturally in foods, so that should be your preferred source.

Weight gain is not a commonly reported side effect of L-methylfolate. However, individual responses to supplements can vary, and factors like diet, lifestyle, and overall health can influence weight changes.

Methylfolate (Methyl B9) and Methyl B12 are both methylated B vitamins. However, they are distinctly different methylated nutrients with specific roles and responsibilities in one-carbon metabolism.

Methylfolate has stereoisomers in the form of diastereoisomers. “L” or “6S” isomer is the active form of methylfolate. This is also known as: Levomefolate.

Does l-methylfolate really work? ›

Clinical Points

In this real-world study, patients with depression taking l-methylfolate reported significant improvements in depressive symptoms and functioning, with 67.9% of patients responding and 45.7% achieving remission over 12 weeks.

Folyx Tablet contains L-Methylfolate calcium 1mg, an active form of folic acid. Due to current lifestyles, food habits, sedentary life, varied diseases, MTHFR Gene Polymorphism, Folic acid may not be beneficial due to its less bioavailability, ins uch cases Folyx is an ideal choice.

Methylfolate is the biologically active form of vitamin B9. Taking too much methylfolate can cause side effects, such as severe anxiety, nausea, insomnia, migraines, irritability, achy joints, headaches, and more.

Interactions between your drugs

No interactions were found between l-methylfolate and Vitamin D3.

People who suffer from depression, anxiety or bipolar disorder may be helped by taking methylfolate supplements. The higher levels of hom*ocysteine typically experienced by people who don't have enough methylfolate can also affect memory, with the possibility of dementia and Alzheimer's disease being linked with this.

L-methylfolate is a form of folate, or vitamin B9, that can help regulate serotonin and dopamine levels. Because these chemicals affect mood, some people believe taking l-methylfolate may help with depression. However, research on this so far has found mixed results .

5-MTHF plays an essential role in methylation, it enables the conversion of hom*ocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA.

For women, one sign of not having enough methylfolate can be fertility-related issues. Low levels of methylfolate can impact the way the body deals with estrogen, which can cause hormonal imbalances. This can cause symptoms such as heavy periods, fibroids, endometriosis and polycystic ovary syndrome (PCOS).

You can take methylfolate with or without food, with or without other supplements, at any time of day (though some experts believe taking it in the morning or at lunchtime is most beneficial). There are also no reported adverse reactions with other medications, but as always, check with your doctor.