Magnafolate Jinkang on LinkedIn: #magnafolate #activefolate #l5mthf #5mthf #l5mthfca #lmethylfolate… (2024)

Folate and Fertility ...Today approximately 15% of all reproductive-aged couples worldwide are struggling with fertility issues. In real terms, this translates to 48 million couples.One reason for infertility can be a folate deficiency, and a simple blood test can confirm if this is the case. Folate is naturally found in broccoli,sproutsand leafy green vegetablesbut unfortunately, for many today, green vegetables, cabbage and salad leaves do not feature regularly in the diet.A diet of ready meals or highly processed foods may contain sources of folate but processing and storage often render these sources inactive.Incorporating fresh vegetables into the diet is the best way forward.Folate deficiency can occur for a variety of health reasons, including renal and liver dysfunction, conditions known to cause malabsorption and poor gastrointestinal motility, and alcohol and drug misuse. It can also occur as a result of a genetic mutation.The MTHFR gene directly impacts folate metabolism and is thought to affect 40% of the global population to varying degrees. This gene is responsible for the production of the MTHFR enzyme which is important for the process of methylation.Methylation is a first-line essential biochemical process in the transmission of life, playing a critical role in the modification of DNA and histones, proteins that provide structural support for each chromosome. Methylation is involved in regulating gametogenesis, embryonic and placental growth, as well as imprinting and epigenesis.All essential to the development of new life.hom*ocysteineis produced as a result of methylation reactions. Well known as the bad guy responsible for heart disease, weactuallyneed hom*ocysteine to make glutathione, the body’s homemade antioxidantwhich protects all cells.Glutathione has a positive impact as regards the prevention of autoimmune issues that can adversely affect conception.Low folate levels directly contribute to the creation of too much hom*ocysteine, and this too creates a risk factor for embryo loss in early pregnancy. (hom*ocysteine levels can also be tested with a simple blood test.)The potential issues created by a mutation of the MTHFR gene can be rectified by supplementing with (6S)-5-Methyltetrahydrofolate under the brand name, Quatrefolic. It is the only biological supplemental form of folate and is the most commonly found folate in maternal blood serum and in the blood carried in the umbilical cord.Quatrefolic has been shown to be of benefit for couples with a history of miscarriage, particularly where hom*ocysteine levels were abnormally high. The studies* undertaken found 400 mcg daily to be valuable but this should always be discussed and monitored by your healthcare provider.*Clement et al 2020 and Servy et al 2018#folate #quatrefolic #fertility #fertilityawareness #miscarriage #pregnancyloss #pregnancylossawareness #pregnancy #highriskpregnancy #reproductivehealth

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𝐂𝐨𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐲 𝐒𝐞𝐫𝐢𝐞𝐬 - 𝐑𝐞𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐯𝐞 𝐇𝐞𝐚𝐥𝐭𝐡𝘋̲𝘺̲𝘥̲𝘳̲𝘰̲𝘨̲𝘦̲𝘴̲𝘵̲𝘦̲𝘳̲𝘰̲𝘯̲𝘦̲ (̲𝘋̲𝘶̲𝘱̲𝘩̲𝘢̲𝘴̲𝘵̲𝘰̲𝘯̲)̲ 𝘊̲𝘰̲𝘶̲𝘯̲𝘴̲𝘦̲𝘭̲𝘭̲𝘪̲𝘯̲𝘨̲𝐃𝐲𝐝𝐫𝐨𝐠𝐞𝐬𝐭𝐞𝐫𝐨𝐧𝐞 is a synthetic orally active progesterone indicated for a wide range of progesterone deficiencies and Hormone Replacement Therapy. It works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.𝐀𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐒𝐭𝐫𝐞𝐧𝐠𝐭𝐡𝐬⏺ 10 mg (Duphaston)𝐈𝐧𝐝𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬✅ 𝙿̲𝚛̲𝚘̲𝚐̲𝚎̲𝚜̲𝚝̲𝚎̲𝚛̲𝚘̲𝚗̲𝚎̲ 𝚍̲𝚎̲𝚏̲𝚒̲𝚌̲𝚒̲𝚎̲𝚗̲𝚌̲𝚒̲𝚎̲𝚜̲:̲ Dysmenorrhea, endometriosis, irregular cycles, dysfunctional uterine bleeding, premenstrual syndrome, threatened miscarriage, habitual miscarriage, infertility due to luteal deficiency, luteal support in Assisted Reproductive Technology.✅ 𝙷̲𝚘̲𝚛̲𝚖̲𝚘̲𝚗̲𝚎̲ 𝚁̲𝚎̲𝚙̲𝚕̲𝚊̲𝚌̲𝚎̲𝚖̲𝚎̲𝚗̲𝚝̲ 𝚃̲𝚑̲𝚎̲𝚛̲𝚊̲𝚙̲𝚢̲𝐔𝐬𝐮𝐚𝐥 𝐃𝐨𝐬𝐞⏺ 10 mg twice daily (subject to specific conditions)𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐢𝐬𝐭 𝐖𝐨𝐫𝐤𝐮𝐩❌ Duphaston contains 𝐥𝐚𝐜𝐭𝐨𝐬𝐞. Therefore it is contraindicated in patients with lactose intolerance conditions (galactose intolerance, Lapp lactase deficiency, etc.)❌ The drug is largely metabolized by liver 𝐂𝐘𝐏𝟑𝐀𝟒. Therefore contraindicated in liver disorders (acute, chronic, porphyrias).✖ Similarly, 𝐂𝐘𝐏𝟑𝐀𝟒 inducers increase the metabolism, reducing efficacy. Counsel patients about the concomitant use of these medicines. (Can you name some CYP3A4 inducers? 😃)⚓ Thirdly, the drug is 90% 𝐩𝐫𝐨𝐭𝐞𝐢𝐧-𝐛𝐨𝐮𝐧𝐝. (Do you know what that means? 🍺)⛑️ Guide patients about the possible common side effects of the medicine which may include but are not limited to vagin*l hemorrhage, headaches, menstrual disorders, and breast pain)🤱 Patients can use it during pregnancy but not to be used during the lactation period.👥 Adolescents (under 18) can also use this medicine.

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Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted #Metabolomics Analyses of Participants from the Early Pregnancy Study.ABSTRACT: BACKGROUND: Parabens, found in everyday items from personal care products to foods, are chemicals with endocrine-disrupting activity, which has been shown to influence reproductive function. OBJECTIVES: This study investigated whether urinary concentrations of methylparaben, propylparaben, or butylparaben were associated with the urinary metabolome during the periconceptional period, a critical window for female reproductive function. Changes to the periconceptional urinary metabolome could provide insights into the mechanisms by which parabens could impact fertility. METHODS: Urinary paraben concentrations were measured in paired pre- and postconception urine samples from 42 participants in the Early Pregnancy Study, a prospective cohort of 221 women attempting to conceive. We performed untargeted and targeted metabolomics analyses using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry. We used principal component analysis, orthogonal partial least-squares discriminant analysis, and permutation testing, coupled with univariate statistical analyses, to find metabolites associated with paraben concentration at the two time points. Potential confounders were identified with a directed acyclic graph and used to adjust results with multivariable linear regression. Metabolites were identified using fragmentation data. RESULTS: Seven metabolites were associated with paraben concentration (variable importance to projection score > 1, false discovery rate-corrected q-value < 0.1). We identified four diet-related metabolites to the Metabolomics Standards Initiative (MSI) certainty of identification level 2, including metabolites from smoke flavoring, grapes, and olive oil. One metabolite was identified to the class level only (MSI level 3). Two metabolites were unidentified (MSI level 4). After adjustment, three metabolites remained associated with methylparaben and propylparaben, two of which were diet-related. No metabolomic markers of endocrine disruption were associated with paraben concentrations. DISCUSSION: This study identified novel relationships between urinary paraben concentrations and diet-related metabolites but not with metabolites on endocrine-disrupting pathways, as hypothesized. It demonstrates the feasibility of integrating untargeted metabolomics data with environmental exposure information and epidemiological adjustment for confounders. The findings underscore a potentially important connection between diet and paraben exposure, with applications to nutritional epidemiology and dietary exposure assessment. https://lnkd.in/gKFk4JeS.Source: Environ Health Perspect https://lnkd.in/g2zwY4jU

👨⚕️ Enhance quality with FertyBiotic Restore®! 🌱🔬 At Fertypharm, we're proud to introduce FertyBiotic Restore®, a specialized food supplement with Lactobacillus rhamnosus and Bifidobacterium longum to contribute to sem*n quality. 🚀  Key Advantages supported by scientific research:  🏃♂️ Boost Sperm Motility: Our supplement aids in improving sperm motility by providing antioxidant and anti-inflammatory properties.  🔗 Reduce Sperm DNA Fragmentation: Witness a decrease in DNA fragmentation after just 21 days of using FertyBiotic Restore®, safeguarding and preserving sperm DNA integrity.  In summary, FertyBiotic Restore® is a probiotic solution applicable to male fertility. 🌟 For fertility specialists, consider this as an option to aid your patients in achieving their reproductive goals.  Share your thoughts or experiences with male fertility in the comments! 📢💬   Blibiography: K. Oleszczuk, L. Augustinsson, N. Bayat, A. Giwercman and M. Bungum. Prevalence of high DNA fragmentation index in male partners of unexplained infertile couples. 2013;1:357-360.E. Seminal bacterial contaminations: Probable factor in unexplained recurrent pregnancy loss. Iran J Reprod Med. 2013;11(11):8.Moretti E, Capitani S, Figura N, Pammolli A, Federico MG, Giannerini V, et al. The presence of bacterial species in sem*n and sperm quality. J Assist Reprod Genet. January 2009;26(1):47-56.Havrylyuk A, Chopyak V, Boyko Y, Kril I, Kurpisz M. Cytokines in the blood and sem*n of infertile patients. Cent Eur J Immunol. 2015;3:337-44.Martínez P, Proverbio F, Camejo MI. Sperm lipid peroxidation and pro-inflammatory cytokines. Asian J Androl. January 2007;9(1):102-7.Robles V, García Valcarce D, Vidal DR, Genovés S, Martorell P, Chenoll MA. Use of probiotics to increase male fertility.Valcarce DG, Riesco MF, Martínez-Vázquez JM, Robles V. Diet Supplemented with Antioxidant and Anti-Inflammatory Probiotics Improves Sperm Quality after Only One Spermatogenic Cycle in Zebrafish Model. Nutrients. April 13, 2019;11(4):843.Valcarce DG, Genovés S, Riesco MF, Martorell P, Herráez MP, Ramón D, et al. Probiotic administration improves sperm quality in asthenozoospermic human donors. Benef Microbes. April 26, 2017;8(2):193-206 #MaleFertility #FertilitySolutions #ProbioticsForMen #HealthForMen #FertilitySupport #FertilityScience #MaleWellness #sem*nQuality #HealthySperm #FertilitySpecialists #MenHealthCare #ScienceBacked #HealthyLiving #MaleReproductiveHealth #WellnessJourney #FertyBioticRESTORE 

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Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted #Metabolomics Analyses of Participants from the Early Pregnancy StudyAbstractBackground:Parabens, found in everyday items from personal care products to foods, are chemicals with endocrine-disrupting activity, which has been shown to influence reproductive function.Objectives:This study investigated whether urinary concentrations of methylparaben, propylparaben, or butylparaben were associated with the urinary metabolome during the periconceptional period, a critical window for female reproductive function. Changes to the periconceptional urinary metabolome could provide insights into the mechanisms by which parabens could impact fertility.Methods:Urinary paraben concentrations were measured in paired pre- and postconception urine samples from 42 participants in the Early Pregnancy Study, a prospective cohort of 221 women attempting to conceive. We performed untargeted and targeted metabolomics analyses using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry. We used principal component analysis, orthogonal partial least-squares discriminant analysis, and permutation testing, coupled with univariate statistical analyses, to find metabolites associated with paraben concentration at the two time points. Potential confounders were identified with a directed acyclic graph and used to adjust results with multivariable linear regression. Metabolites were identified using fragmentation data.Results:Seven metabolites were associated with paraben concentration (variable importance to projection score>1 , false discovery rate–correctedp-value<0.1). We identified four diet-related metabolites to the Metabolomics Standards Initiative (MSI) certainty of identification level 2, including metabolites from smoke flavoring, grapes, and olive oil. One metabolite was identified to the class level only (MSI level 3). Two metabolites were unidentified (MSI level 4). After adjustment, three metabolites remained associated with methylparaben and propylparaben, two of which were diet-related. No metabolomic markers of endocrine disruption were associated with paraben concentrations.Discussion:This study identified novel relationships between urinary paraben concentrations and diet-related metabolites but not with metabolites on endocrine-disrupting pathways, as hypothesized. It demonstrates the feasibility of integrating untargeted metabolomics data with environmental exposure information and epidemiological adjustment for confounders. The findings underscore a potentially important connection between diet and paraben exposure, with applications to nutritional epidemiology and dietary exposure assessment.https://lnkd.in/g2zwY4jU

📃Scientific paper: Environmental and parental risk factors for congenital solitary functioning kidney — a case–control studyAbstract:Background The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors.We performed a case–control study to compare exposure to environmental and parental risk factors during embryonic kidney development between children with CSFK and healthy controls.Methods We included 434 children with CSFK and 1302 healthy controls from the AGORA data- and biobank matched on year of birth.Exposure to potential risk factors was investigated using parental questionnaire data.Crude and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were estimated for each potential risk factor.Multiple imputation was used to deal with missing values.Confounders for each potential risk factor were selected using directed acyclic graphs.Results Maternal stress was newly identified as a risk factor for CSFK (aOR 2.1, 95% CI 1.2–3.5).Known associations with conception using in vitro fertilization/intracytoplasmic sperm injection (aOR 1.8, 95% CI 1.0–3.2), maternal infections during pregnancy (aOR 2.5, 95% CI 1.4–4.7), smoking during pregnancy (aOR 1.4, 95% CI 1.0–2.0), and parental CAKUT (aOR 6.6, 95% CI 2.9–15.1) were confirmed, but previous associations with diabetes and obesity could not be replicated.Folic acid supplement use and younger maternal age seemed to reduce the risk of CSFK (aORs 0.7, 95% CI 0.5–1.0, and 0.8, 95% CI 0.6–1.0, respectively).Conclusions Environmental and parental risk factors are likel...Continued on ES/IODE ➡️ https://etcse.fr/26A-------If you find this interesting, feel free to follow, comment and share.We need your help to enhance our visibility, so that our platform continues to serve you.

Hormone assays conducted in clinical laboratories often focus on fertility hormones, particularly those relevant to women. For men, testosterone is typically the primary or sole fertility hormone assessed, reflecting a common practice where prolactin testing is often overlooked.However, hyperprolactinemia, characterized by elevated prolactin levels in the blood, is recognized as a significant factor in male infertility. This condition, affecting approximately 1% of the global population, is commonly caused by a benign pituitary tumor known as a prolactinoma. Other contributors include conditions like chronic kidney disease, hypothyroidism (insufficient thyroid hormone production), and certain medications.Wheat, rye, and barley are all high in gluten, which may cause an inflammatory response in the body when consumed. This could increase the prolactin level and disrupt dopamine production in the hypothalamus. Thus, avoiding gluten could prove to be an effective way to lower prolactin levels.Serum prolactin levels can also rise notably due to exercise or stress in both men and women. When elevated prolactin disrupts testicular function, it can lead to reduced testosterone production and sperm count. Consequently, low testosterone levels can result in decreased energy, libido, muscle mass, strength, and potentially anemia.Normal prolactin values vary; in men, they typically range below 20 ng/mL, though levels up to 25 ng/mL are considered normal for Women. Prolactin is primarily metabolized by the liver (75%) and kidneys (25%). Baseline prolactin levels average around 13 ng/mL in women and 5 ng/mL in men, with a reference range of 3-13 ng/mL for adult males.

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Improving IVF Success With SupplementsFertility-boosting supplements may help with IVF. Co-Q10 and omega-3 fatty acids are effective while vitamin D and E have mixed results.#supplements #ivf #vitamins #apthorprxhttps://zurl.co/fBCL

SEQUENTIAL vagin*L ESTRADIOL AND PROGESTERONE CORRECT THE ACTION OF CLOMIPHENE ON THE ENDOMETRIUM#clomiphene #infertility #endometriumClomiphene citrate (CC), a synthetic, non-steroidal estrogen receptor agonist and antagonist is used to induce ovulation in women suffering from chronic oligo-anovulation. CC therapy induces ovulation by increasing pituitary gonadotrophin output via a blockage of the normal negative feedback exerted by estrogens on hypothalamic GnRH release. The resulting increase in circulating FSH and LH levels triggered by CC administration initiates follicular maturation and ultimately leads to ovulation. Treatment with CC at a dosage of 50 or 100 mg/day for 5 days succeeds in inducing ovulation in 50–75% of women suffering from chronic oligo-anovulation, but the number of pregnancies achieved is much lower than would be expected based on ovulation rates.Adverse effects of CC on the endometrium are likely to be the primary cause of the suboptimal pregnancy rates seen when ovulation is induced with CC. It has long been recognized that women who receive CC for ovulation induction demonstrate a delay in endometrial stromal development, resulting in out of phase endometrial biopsies performed in the late luteal phase.Studies of the endometrium after exposure to CC have shown a high incidence of histological features consistent with hypo-estrogenic effects, suggesting that the lack of progestational effects seen in the late luteal phase may stem from anti-estrogenic effects resulting in insufficient development of estrogen receptors (ER) and progesterone receptors (PR).In a study using hormonal supplementationa timed sequence of vagin*l hormone supplementation (HS) with estradiol (E2) and progesterone gel following CC therapyto correct the endometrial disorders that progesterone alone fails to achieve. Both hormones were administered vagin*lly in order to optimize endometrial concentrations, since evidence supports that vagin*lly administered E2and progesterone result in higher endometrial concentrations of these hormones than when administered otherwise.Results clearly showed that exogenous vagin*l E2and progesterone improved endometrial morphology of CC-treated patients.This study demonstrated that hormonal supplementation with vagin*l E2and progesterone resulted in in-phase endometrial development in 100% of women following CC-induced ovulation.https://lnkd.in/eszbhgRB

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1. Why are women with polycystic ovary syndrome obese?Polycystic ovary syndrome (PCOS) is a condition that affects women's hormonal levels. Women with PCOS produce a higher amount of male hormones called androgens compared to normal women. This hormonal imbalance causes women with PCOS to skip their menstrual periods, making it difficult for them to get pregnant. One of the main factors contributing to the development of PCOS is obesity. It has been linked to many metabolic and reproductive disorders, including PCOS. (http://surl.li/rcjdl)2. Why is Early Diagnosis and Treatment of PCOS Important?As with any chronic disease, early detection is crucial in managing PCOS effectively. PCOS increases the likelihood of other diseases, such as high blood pressure, type 2 diabetes, sleep apnea, abnormal uterine bleeding, cholesterol abnormalities, metabolic syndrome, heart disease, uterine cancer, and complications during pregnancy. Early diagnosis and treatment can help reduce the risk of these long-term complications. (http://surl.li/rciys)3. PCOS MedicationThere is no single drug to treat PCOS, and in some cases, lifestyle changes may be sufficient. However, many women will be prescribed drugs to help manage individual symptoms or achieve specific goals, such as getting pregnant. (http://surl.li/rcjvf)4. Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata (LPva) for Polycystic Ovary Syndrome TreatmentVarious studies on Labisia pumila (LP) and its variants in PCOS rat models demonstrate positive effects, including increased uterine weight, improved insulin sensitivity, and enhanced lipid profile. LP extracts show promise as cost-effective and safe alternatives, with potential benefits in PCOS-related inflammation reduction and osteoporosis prevention. LP, with phytoestrogenic and antioxidant capabilities, emerges as a potential alternative for managing PCOS conditions. (http://surl.li/rcjbi, http://surl.li/rcjdl, http://surl.li/rcjfo, http://surl.li/rcjin, http://surl.li/rcjhu)5. SKF7® (Standardized extract Labisia pumila) by Medika Natura Sdn Bhd Our commitment to safety is demonstrated through rigorous safety studies aligning with OECD GLP standards. The efficacy of SKF7® is proven in clinical studies targeting obesity and pre-clinical studies on cancer, diabetes, fibroids, and COVID-19. SKF7® is now in the market, certified as a Halal pharmaceutical product. Various studies on Labisia pumila (LP) and its variants in PCOS rat models demonstrate positive effects, including increased uterine weight, improved insulin sensitivity, and an enhanced lipid profile. SKF7® emerges as an alternative to synthetic drugs for PCOS, while avoiding reported adverse events.Additional clinical research is essential to determine Labisia pumila's efficacy and applications compared to synthetic PCOS treatments. Explore Labeesity SKF7®'s clinical benefits on MIMS at https://lnkd.in/gBD8dEie.#PCOS #obesity #womenhealth